海外

Postdoctoral position in electrophysiology of Alzheimer’s Disease : Belgium
Employer: VIB
Location: Herestraat 49, 3000 Leuven, BELGIUM, Belgium
Type: Other
Posted: December 22, 2011
Expires: June 30, 2012
Requisition number: Euraxess-euraxess-jobs-33754690

job description

Electrophysiology of Alzheimer’s Disease
Description

γ-secretase is involved in Alzheimer's Disease (AD) since it produces the Amyloid-beta protein that aggregates in the amyloid plaques of AD patients (De Strooper, Neuron, 2003). Different γ-Secretase complexes exist that can regulate specific cognitive functions (Dejaegere al., PNAS, 2008; Serneels et al., Science, 2009). In addition to the production of Amyloid-beta, γ-Secretase controls other proteins that are important for neuronal function. Among them, we found APP, Notch and the schizophrenia risk genes Nrg1 and ErbB4 (Fazzari et al., Nature, 2010). However, the physiological role of γ-Secretase in the brain is still poorly understood. In this research project, we aim to determine the specific role of diverse γ-Secretase complexes in the maintenance of brain circuits. The job will involve electrophysiological recordings in different mutant γ-secretase mice available in the lab in combination with selective genetic experiments at the cellular level using viral transduction to inactivate specific gamma-secretase complexes in different areas of the brain. There is ample opportunity to interact with a multidisciplinary and international team of dedicated scientists to unravel the molecular and cell biology role of the different γ-secretases.
Benefits

We offer an excellent postdoctoral position in an international research institute in the center of Europe (close to Brussels and fast train connections to Paris, London, Cologne and Amsterdam), with access to high end technology, core facilities, technical support and a brand new research building. Good knowledge of English is sufficient for all communications both within and outside of the institute.中国留学人才网（海归人才网）http://www.liuxuehr.com 为广大海外高层次人才提供回国就业、创业机会，关注海归生活。高层次人才交流QQ群：106247053 留学人才网微博：http://weibo.com/liuxuehr