海外

Research Description: Opportunity exists for Post-Doc to join a multi-disciplinary team to develop endoscope compatible optical imaging instruments for novel technologies including dual axes confocal, multi-photon, and photoacoustic endomicroscopy. Applications include the clinical translation of minimally invasive optical instruments for the early detection of cancer. These novel enabling technologies are being developed to provide real-time non-invasive “optical biopsy” in situ with great potential to improve current clinical diagnosis. Projects involve the integration of optical fibers, micro-optics, lasers, and detectors with microelectromechanical systems (MEMS) devices, including packaging of micro-mirrors and actuators, development of software for data acquisition, control of instrument devices, and image collection, processing, and analysis. A systems approach will be undertaken to integrate ultra-fast pulse lasers, semi-conductor lasers, miniature optics, ultra-compact scanners, and data acquisition capabilities on a pc-based platform. Scientific investigation will be conducted in device characterization, performance validation, image interpretation, quantitative analysis, in vivo animal model imaging, clinical translation/applications, and demonstration of novel in vivo contrast agents. There will be ample opportunities to collaborate with molecular biologists, biochemists, and academic physicians in Phase 1 clinical studies. The successful candidate will join a highly collaborative translational research program in the emerging field of molecular endomicroscopy in the Network for Translational Research (http://sitemaker.umich.edu/ntr) and the Barrett’s Esophagus Translational Research Network (http://sitemaker.umich.edu/betrnet) at the University of Michigan.

Requirements: Candidates with a Ph.D. in Engineering, Optics, Physics or related discipline and hands-on experience optical design, optical imaging systems, optical system fabrication, instrument packaging or fiber optic systems are invited to apply. Experience with Zemax, Solid Works, Labview or Matlab is desired.

Environment: The Research Centers for the Network for Translational Research (NTR) and the Barrett’s Esophagus Translational Research Network (BETRNet) are located in the Biomedical Science Research Building (BSRB). This modern research facility conveniently located in between the College of Engineering and School of Medicine at the University of Michigan. The BSRB houses the Center for Molecular Imaging (CMI) (www.med.umich.edu/msair), a state-of-the-art small animal imaging facility, that has instruments for performing real time imaging, including Olympus FV1000MPE Twin two photon microscope with Spectra-Physics Deep See femtosecond lasers ( tunable 690-1040 nm), IVIS Spectrum, 200, and 100 (Caliper), Siemens Inveon PET/CT, GE Healthcare integrated eXplore speCZT/CT 120, and two Varian horizontal bore MRI systems (9.4 and 7 T).

Contact: Candidates should submit CV and contact information by email to tdwangmd@gmail.com:

Thomas D. Wang, M.D.,Ph.D.
Associate Professor of Medicine and Biomedical Engineering
University of Michigan
109 Zina Pitcher Pl. BSRB 1522
Ann Arbor, MI 48109-2200
Email: tdwangmd@gmail.com

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