海外

Postdoctoral Scientist - Cell Signalling Group : Manchester, UK
Employer: Paterson Institute for Cancer Research
Website: http://www.paterson.man.ac.uk
Location: Manchester, UK
Type: Postdoctoral
Posted: November 03, 2011
Expires: December 04, 2011
Jobs by tag(s): paterson institute for cancer research manchester united kingdom postdoctoral postdoc Phd biochemistry cell biology molecular biology biomedical research
Requisition number: PI/11/34

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job description

Postdoctoral Scientist – Cell Signalling Group

Job Ref: PI/11/34
Salary in the range of £28,500 – £38,000 dependent upon qualifications and experience
3 year fixed term contract

The Paterson Institute is a leading cancer centre of excellence core-funded by Cancer Research UK and is an Institute of The University of Manchester.

A position is available in the laboratory of Angeliki Malliri for an ambitious, highly skilled and creative post-doctoral scientist to investigate the regulation of the Rho-like GTPase Rac1 as well as its activator Tiam1 by post-translational modifications and the influence of such modifications on cell migration, invasion and cell–cell adhesion.

You should have a PhD and background in biochemistry, cell biology or molecular biology and be highly motivated to pursue a career in biomedical research.

Recent publications from our lab include:

1. Castillo-Lluva et al. (2010) SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nature Cell Biology 12, 1078-1085.

2. Woodcock et al. (2010) Tiam1-Rac signalling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression. Current Biology 20, 669-675.

3. Rooney et al. (2010) The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep. 11, 292-298.

4. Woodcock et al. (2009) Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1. Molecular Cell 33, 639–653.

Informal enquiries should be directed to Angeliki Malliri amalliri@picr.man.ac.uk

To apply for these positions please visit our website: www.paterson.man.ac.uk

For applicants who are unable to download this information from our website, please contact HR department on 0161 446 3231, email: jobs@picr.man.ac.uk to have this information sent by post.

Closing date: 4 December 2011