海外

The lab is interested in understanding the mechanisms that contribute to metastases of breast cancer cells. Specifically we are interested in understanding how breast cancer cells regulate anchorage-independent survival to overcome anoikis, or cell death that results from loss of appropriate extracellular matrix cues. In contrast to normal epithelial cells, which are unable to survive deprivation of matrix signals that help maintain normal tissue architecture, tumor cells are able to survive in altered matrix environments, thereby promoting their dissemination and colonization of distant metastatic sites. We are using genomic and screen-based approaches to develop a comprehensive picture of the molecules and pathways that regulate oncogene-driven anoikis resistance. Our high throughput screen for novel anoikis regulators identified several candidates that are currently being evaluated as potential therapeutic targets for specific breast cancer subtypes. The post-doctoral fellow/staff scientist will develop projects to elucidate the mechanistic basis for regulation of anoikis resistance by these candidates and to evaluate the ability of these candidates to regulate metastases in breast cancer models.

Prerequisites: M.D. and/or Ph.D. with clinical or research experience in the fields of oncology, cancer biology or cancer genetics.

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